[CAS NO. 1082949-67-4] LY2584702
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PRODUCTS SPECIFICATIONS [1082949-67-4]
Catalog
SLK-S7698
Brand
Selleck
CAS
1082949-67-4
DESCRIPTION [1082949-67-4]
Overview
| MDL | MFCD18633220 |
|---|---|
| Molecular Weight | 445.42 |
| Molecular Formula | C21H19F4N7 |
| SMILES | CN1C=C(C2=CC=C(F)C(C(F)(F)F)=C2)N=C1C3CCN(C4=C5C(NN=C5)=NC=N4)CC3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2451 mL | 11.2254 mL | 22.4507 mL |
| 5 mM | 0.4490 mL | 2.2451 mL | 4.4901 mL |
| 10 mM | - | - | - |
| 50 mM | - | - | - |
Description
LY2584702 is a selective, ATP-competitive inhibitor with of 4 nM.
Targets
| p70S6K [1] |
| 4 nM |
In vitro
In HCT116 colon cancer cells, LY2584702 inhibits phosphorylation of the S6 ribosomal protein (pS6) with IC50 of 0.1-0.24 μM. LY2584702 has significant synergistic effects when combined with EGFR inhibitor erlotinib or with the mTOR inhibitor everolimus.
References
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