[CAS NO. 872573-93-8]  Ro-3306

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PRODUCTS SPECIFICATIONS [872573-93-8]

Catelog
SLK-S7747
Brand
Selleck
CAS
872573-93-8

DESCRIPTION [872573-93-8]

Overview

MDLMFCD17392573
Molecular Weight351.45
Molecular FormulaC18H13N3OS2
SMILESO=C1N=C(NCC2=CC=CS2)S/C1=C/C3=CC=C4N=CC=CC4=C3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM2.8454 mL14.2268 mL28.4535 mL
5 mM0.5691 mL2.8454 mL5.6907 mL
10 mM0.2845 mL1.4227 mL2.8454 mL
50 mM0.0569 mL0.2845 mL0.5691 mL

Description

RO-3306 is an ATP-competitive, and selective inhibitor with of 20 nM, >15-fold selectivity against a diverse panel of human kinases. RO-3306 enhances p53-mediated activation and .

Targets

CDK1 [1]
(Cell-free assay)
PKCδ [1]
(Cell-free assay)
SGK [1]
(Cell-free assay)
ERK [1]
(Cell-free assay)
20 nM(Ki)318 nM(Ki)497 nM(Ki)1980 nM(Ki)

In vitro

RO-3306 inhibits CDK1/cyclin B1, CDK1/cyclin A, CDK2/cyclin E, and CDK4/cyclin D activity with Ki of 35 nM, 110 nM, 340 nM, and over 2000 nM, respectively. Treatment of HCT116, SW480, and HeLa cells with RO-3306 for 20 h leads to a complete block of the cell cycle in the G2/M phase. The proliferation of both HCT116 and SW480 is effectively blocked by RO-3306. RO-3306 appears to be more proapoptotic in cancer cells (HCT116 and SW480) than nontumorigenic cells (MCF 10A and MCF 12A).RO-3306 effectively arrests oocyte maturation at a concentration of 10 μM.