[CAS NO. 872573-93-8] Ro-3306
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PRODUCTS SPECIFICATIONS [872573-93-8]
Catalog
SLK-S7747
Brand
Selleck
CAS
872573-93-8
DESCRIPTION [872573-93-8]
Overview
| MDL | MFCD17392573 |
|---|---|
| Molecular Weight | 351.45 |
| Molecular Formula | C18H13N3OS2 |
| SMILES | O=C1N=C(NCC2=CC=CS2)S/C1=C/C3=CC=C4N=CC=CC4=C3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.8454 mL | 14.2268 mL | 28.4535 mL |
| 5 mM | 0.5691 mL | 2.8454 mL | 5.6907 mL |
| 10 mM | 0.2845 mL | 1.4227 mL | 2.8454 mL |
| 50 mM | 0.0569 mL | 0.2845 mL | 0.5691 mL |
Description
RO-3306 is an ATP-competitive, and selective inhibitor with of 20 nM, >15-fold selectivity against a diverse panel of human kinases. RO-3306 enhances p53-mediated activation and .
Targets
In vitro
RO-3306 inhibits CDK1/cyclin B1, CDK1/cyclin A, CDK2/cyclin E, and CDK4/cyclin D activity with Ki of 35 nM, 110 nM, 340 nM, and over 2000 nM, respectively. Treatment of HCT116, SW480, and HeLa cells with RO-3306 for 20 h leads to a complete block of the cell cycle in the G2/M phase. The proliferation of both HCT116 and SW480 is effectively blocked by RO-3306. RO-3306 appears to be more proapoptotic in cancer cells (HCT116 and SW480) than nontumorigenic cells (MCF 10A and MCF 12A).RO-3306 effectively arrests oocyte maturation at a concentration of 10 μM.
References
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