[CAS NO. 254750-02-2] Emricasan (IDN-6556)

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Catalog:	SLK-S7775
Brand:	Selleck
CAS:	254750-02-2

Overview

MDL	MFCD11840420
Molecular Weight	569.50
Molecular Formula	C26H27F4N3O7
SMILES	N(C(C(N[C@H](C(N[C@H](C(COC1=C(F)C(F)=CC(F)=C1F)=O)CC(O)=O)=O)C)=O)=O)C2=C(C(C)(C)C)C=CC=C2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

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Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.7559 mL	8.7796 mL	17.5593 mL
5 mM	0.3512 mL	1.7559 mL	3.5119 mL
10 mM	0.1756 mL	0.8780 mL	1.7559 mL
50 mM	0.0351 mL	0.1756 mL	0.3512 mL

Description

Emricasan (IDN-6556, PF 03491390, PF-03491390) is a potent irreversible inhibitor. Emricasan is an inhibitor of Zika virus infection.

Targets

caspase ^[1]

In vitro

Emricasan, also called IDN-6556 or PF-03491390, is an inhibitor of activated caspases, and it has sub- to nanomolar activity in vitro. Emricasan shows neuroprotective activity for hNPCs but does not suppress ZIKV replication.

In vivo

Emricasan decreases liver injury but not metabolic derangement in NASH. It also ameliorates inflammation. In the murine NASH model, stellate cell activation and hepatic fibrogenesis are attenuated by administration of the pan-caspase inhibitor Emricasan. Emricasan is currently being evaluated in phase 2 clinical trials for the reduction of hepatic injury and liver fibrosis caused by chronic HCV infection.

References

[1] Barreyro FJ, et al. Liver Int. 2015, 35(3):953-66.
[2] Xu M, et al. Nat Med. 2016, [Epub ahead of print].

Synonyms

L-Alaninamide, N-[2-(1,1-dimethylethyl)phenyl]-2-oxoglycyl-N-[(1S)-1-(carboxymethyl)-2-oxo-3-(2,3,5,6-tetrafluorophenoxy)propyl]-

N-[2-(1,1-Dimethylethyl)phenyl]-2-oxoglycyl-N-[(1S)-1-(carboxymethyl)-2-oxo-3-(2,3,5,6-tetrafluorophenoxy)propyl]-L-alaninamide

IDN 6556

PF 03491390

Emricasan

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