[CAS NO. 612847-09-3] Akti-1/2
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PRODUCTS SPECIFICATIONS [612847-09-3]
Distributor
Catalog
SLK-S7776
Brand
Selleck
CAS
612847-09-3
DESCRIPTION [612847-09-3]
Overview
| MDL | MFCD09026909 |
|---|---|
| Molecular Weight | 551.64 |
| Molecular Formula | C34H29N7O |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.8128 mL | 9.0639 mL | 18.1278 mL |
| 5 mM | 0.3626 mL | 1.8128 mL | 3.6256 mL |
| 10 mM | 0.1813 mL | 0.9064 mL | 1.8128 mL |
| 50 mM | - | - | - |
Description
Akti-1/2 (Akt Inhibitor VIII) is a highly selective inhibitor with of 58 nM/210 nM, respectively, about 36-fold selectivity for Akt1 over Akt3. Akti-1/2 induces .
Targets
In vitro
In a cell-based IPKA (C33A) assay, Akti-1/2 inhibits Akt1 and Akt2 with IC50 of 305 nM and 2086 nM, respectively. In HT29, MCF7, and A2780 cells, Akti-1/2 induces cell apoptosis by dramatically increasing caspase-3 activity. In liver cells, Akti-1/2 blocks insulin regulation of PEPCK, G6Pase expression, and FOXO1 activity. Akti-1/2 also strongly potentiates PAR-1-mediated platelet aggregation by blocking PKB. In HCC827, NCI-H522, NCI-1651, and PC-9 cells, Akti-1/2 inhibits cell growth with IC50 of 4.7 μM, 7.25 μM, and 9.5 μM, when in combination with gefitinib, Akti-1/2 causes enhanced inhibition of cell growth and apoptosis.
References
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