[CAS NO. 357166-30-4] Pemetrexed Disodium Hydrate
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PRODUCTS SPECIFICATIONS [357166-30-4]
Fulfillment
Catalog
SLK-S7785
Brand
Selleck
CAS
357166-30-4
DESCRIPTION [357166-30-4]
Overview
| MDL | MFCD08458870 |
|---|---|
| Molecular Weight | 516.42 |
| Molecular Formula | C20H21N5O6.5/2H2O.2Na |
| SMILES | O=C1C2=C(NC=C2CCC3=CC=C(C=C3)C(N[C@@H](CCC([O-])=O)C([O-])=O)=O)NC(N)=N1.O=C4C5=C(NC=C5CCC6=CC=C(C=C6)C(N[C@@H](CCC([O-])=O)C([O-])=O)=O)NC(N)=N4.[Na+].[Na+].[Na+].[Na+].O.O.O.O.O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.9364 mL | 9.6820 mL | 19.3641 mL |
| 5 mM | 0.3873 mL | 1.9364 mL | 3.8728 mL |
| 10 mM | 0.1936 mL | 0.9682 mL | 1.9364 mL |
| 50 mM | 0.0387 mL | 0.1936 mL | 0.3873 mL |
Description
Pemetrexed Disodium Hydrate (LY-231514) is a novel antifolate and antimetabolite for TS, and GARFT with of 1.3 nM, 7.2 nM and 65 nM, respectively. Pemetrexed Disodium Hydrate stimulates and .
In vitro
Pemetrexed disodium shows the antiproliferative activity in CCRF-CEM leukemia, GC3/C1 colon carcinoma, and HCT-8 ileocecal carcinoma cells with IC50 of 25 nM, 34 nM and 220 nM, respectively. A recent study shows that cisplatin plus Pemetrexed combined with SOCS-1 gene delivery shows the antitumor effect by inhibition of cell proliferation, invasiveness, and induction of apoptosis in MPM cells infected with adenovirus-expressing SOCS-1 vector.
In vivo
In the human H460 non-small cell lung carcinoma xenograft, Pemetrexed disodium produces a duration-dependent tumor growth delay (TGD).
References
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