[CAS NO. 1668553-26-1]  A-1210477

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PRODUCTS SPECIFICATIONS [1668553-26-1]

Catelog
SLK-S7790
Brand
Selleck
CAS
1668553-26-1

DESCRIPTION [1668553-26-1]

Overview

MDLMFCD28399118
Molecular Weight850.04
Molecular FormulaC46H55N7O7S
SMILESO=C(C(N1CCN2CCOCC2)=C(CCCOC3=C4C=CC=CC4=CC=C3)C5=C1C(C6=C(COC7=CC=C(N8CCN(S(=O)(N(C)C)=O)CC8)C=C7)N(C)N=C6C)=CC=C5)O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM1.1764 mL5.8821 mL11.7642 mL
5 mM---
10 mM---
50 mM---

Description

A-1210477 is a potent and selective inhibitor with and of 0.454 nM and 26.2 nM, respectively, >100-fold selectivity over other Bcl-2 family members.

Targets

MCL-1 [1]
(Cell-free assay)
26.2 nM

In vitro

In H929 cells, A-1210477 binds to MCL-1 with high affinity and induces MCL-1 protein elevation. In H929, H2110, and H23 cells, A-1210477 induce the hallmarks of apoptosis, and inhibits MCL-1-dependent cell viability. A-1210477 also synergizes with navitoclax to kill a variety of cancer cell lines. In SKBR3 cells, A-1210477 inhibits MCL-1–BIM interaction and induces classical features of apoptosis. In addition, A-1210477 sensitizes non-Hodgkin's lymphoma cell lines to venetoclax (ABT-199).