[CAS NO. 1668553-26-1] A-1210477
Please click "REQUEST A QUOTE" button if you need other sizes or
custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis,
please:
PRODUCTS SPECIFICATIONS [1668553-26-1]
Catelog
SLK-S7790
Brand
Selleck
CAS
1668553-26-1
DESCRIPTION [1668553-26-1]
Overview
| MDL | MFCD28399118 |
|---|---|
| Molecular Weight | 850.04 |
| Molecular Formula | C46H55N7O7S |
| SMILES | O=C(C(N1CCN2CCOCC2)=C(CCCOC3=C4C=CC=CC4=CC=C3)C5=C1C(C6=C(COC7=CC=C(N8CCN(S(=O)(N(C)C)=O)CC8)C=C7)N(C)N=C6C)=CC=C5)O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.1764 mL | 5.8821 mL | 11.7642 mL |
| 5 mM | - | - | - |
| 10 mM | - | - | - |
| 50 mM | - | - | - |
Description
A-1210477 is a potent and selective inhibitor with and of 0.454 nM and 26.2 nM, respectively, >100-fold selectivity over other Bcl-2 family members.
Targets
| MCL-1 [1] (Cell-free assay) |
| 26.2 nM |
In vitro
In H929 cells, A-1210477 binds to MCL-1 with high affinity and induces MCL-1 protein elevation. In H929, H2110, and H23 cells, A-1210477 induce the hallmarks of apoptosis, and inhibits MCL-1-dependent cell viability. A-1210477 also synergizes with navitoclax to kill a variety of cancer cell lines. In SKBR3 cells, A-1210477 inhibits MCL-1–BIM interaction and induces classical features of apoptosis. In addition, A-1210477 sensitizes non-Hodgkin's lymphoma cell lines to venetoclax (ABT-199).
References
Powered by Arctom Copyright © 2025 Arctom.
All rights reserved.