[CAS NO. 16561-29-8] Phorbol 12-myristate 13-acetate (PMA)

Name: Phorbol 12-myristate 13-acetate (PMA)
Brand: Arctom Scientific
SKU: SLK-S7791

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PRODUCTS SPECIFICATIONS [16561-29-8]

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Catalog

SLK-S7791

Brand

Selleck

CAS

16561-29-8

DESCRIPTION [16561-29-8]

Overview

MDL	MFCD00036736
Molecular Weight	616.83
Molecular Formula	C36H56O8
SMILES	O(C(C)=O)[C@@]12[C@@](C1(C)C)([C@]3([C@](O)([C@H](C)[C@H]2OC(CCCCCCCCCCCCC)=O)[C@]4([C@](O)(CC(CO)=C3)C(=O)C(C)=C4)[H])[H])[H]

For research use only.

Storage

3 years -20°C(in the dark) powder
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

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Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.6212 mL	8.1060 mL	16.2119 mL
5 mM	0.3242 mL	1.6212 mL	3.2424 mL
10 mM	0.1621 mL	0.8106 mL	1.6212 mL
50 mM	0.0324 mL	0.1621 mL	0.3242 mL

Description

Phorbol 12-myristate 13-acetate (PMA,12-O-Tetradecanoylphorbol-13-acetate, TPA, Phorbol myristate acetate), a potent activator of , is active at nanomolar concentrations. Phorbol 12-myristate 13-acetate (PMA) induces .PMA has strong excitability on the skin and mucous membrane. Special protection is required when using PMA. Wear gloves and mask to avoid direct contact in any way.

In vitro

In endothelial cells, PMA increases levels of Thy-1 mRNA and protein, induces Thy-1 up-regulation and inhibits capillary-like tube formation and endothelial cell migration.

References

[1] Wen HC, et al. Sci Rep. 2018 Nov 2;8(1):16247.

Synonyms

Tetradecanoic acid, (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl ester

Myristic acid, 9-ester with 1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-decahydro-4aβ,7bα,9β,9aα-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one 9a-acetate, (+)-

Tetradecanoic acid, 9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl ester, [1aR-(1aα,1bβ,4aβ,7aα,7bα,8α,9β,9aα)]-

1H-Cyclopropa[3,4]benz[1,2-e]azulene, tetradecanoic acid deriv.

13-O-Acetylphorbol 12-myristate

Phorbol myristate acetate

12-O-Tetradecanoylphorbol 13-acetate

Factor A₁ (croton oil)

12-Tetradecanoylphorbol 13-acetate

Tetradecanoylphorbol acetate

Phorbol 12-tetradecanoate 13-acetate

Phorbol 12-myristate 13-acetate

TPA

Factor A₁

PMA

4β-Phorbol 12-myristate 13-acetate

PMA (tumor promoter)

β-Phorbol 12-myristate 13-acetate

12-Tetradecanoylphorbol 13-monoacetate

TPA (phorbol derivative)

NSC 262244

PD 616