Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
3.2974 mL
16.4870 mL
32.9739 mL
5 mM
0.6595 mL
3.2974 mL
6.5948 mL
10 mM
0.3297 mL
1.6487 mL
3.2974 mL
50 mM
0.0659 mL
0.3297 mL
0.6595 mL
Description
ORY-1001 (RG-6016) 2HCl is an orally active and selective lysine-specific demethylase inhibitor with of <20 nM, with high selectivity against related FAD dependent aminoxidases. Phase 1.
In THP-1 (MLL-AF9) cells, ORY-1001 results in a time/dose dependent me2H3K4 accumulation at KDM1A target genes and concomitant induction of differentiation markers. ORY-1001 also induces apoptosis in THP-1 and inhibits proliferation and colony formation of MV(4;11) (MLL-AF4) cells.
