Overview MDL MFCD30343874 Molecular Weight 510.03 Molecular Formula C27H32ClN5O3 SMILES C(N1C(=CC=2C1=CC=CC2)C=3N(C)C=4C(N3)=CC(C(=O)N5C[C@H](N)[C@H](O)CC5)=CC4OC)C6CC6.Cl
For research use only.
Storage 3 years,-20°C,powder
Shipping Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions Concentration Volume Mass 1 mg 5 mg 10 mg 1 mM 1.9607 mL 9.8033 mL 19.6067 mL 5 mM 0.3921 mL 1.9607 mL 3.9213 mL 10 mM 0.1961 mL 0.9803 mL 1.9607 mL 50 mM 0.0392 mL 0.1961 mL 0.3921 mL
Description GSK484 HCl, a benzoimidazole derivative, is a selective and reversible inhibitor of with IC50 of 50 nM in the absence of Calcium.
Targets PAD4 [1] 50 nM
In vitro GSK484 also inhibits PAD4 citrullination (at 0.2 mM calcium) of benzoyl-arginine ethyl ester (BAEE) substrate in a concentration-dependent manner, as detected using an NH3 release assay. GSK484 causes a clear, statistically-significant reduction in diffused NETs.
Synonyms Methanone, [(3S ,4R )-3-amino-4-hydroxy-1-piperidinyl][2-[1-(cyclopropylmethyl)-1H -indol-2-yl]-7-methoxy-1-methyl-1H -benzimidazol-5-yl]-, hydrochloride (1:1)
