[CAS NO. 1687736-54-4] SGC707
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PRODUCTS SPECIFICATIONS [1687736-54-4]
Catalog
SLK-S7832
Brand
Selleck
CAS
1687736-54-4
DESCRIPTION [1687736-54-4]
Overview
| MDL | MFCD28411624 |
|---|---|
| Molecular Weight | 298.34 |
| Molecular Formula | C16H18N4O2 |
| SMILES | O=C(NCC(N1CCCC1)=O)NC2=CC3=C(C=NC=C3)C=C2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.3519 mL | 16.7594 mL | 33.5188 mL |
| 5 mM | 0.6704 mL | 3.3519 mL | 6.7038 mL |
| 10 mM | 0.3352 mL | 1.6759 mL | 3.3519 mL |
| 50 mM | 0.0670 mL | 0.3352 mL | 0.6704 mL |
Description
SGC707 is a potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 () with and of 31 nM and 53 nM, respectively.
In vitro
In cells, SGC707 binds to PRMT3 and reduces PRMT3-dependent H4R3me2a. SGC707 also stabilizes PRMT3 in both HEK293 and A549 cells with EC50 values of 1.3 μM and 1.6 μM, respectively.
In vivo
In CD-1 male mice, SGC707 (30 mg/kg, i.p.) gives good plasma exposure over 6 h with the peak plasma level of 38000 nM, which suggests that SGC707 is suitable for animal studies.
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