[CAS NO. 76939-46-3] 8-Bromo-cAMP
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PRODUCTS SPECIFICATIONS [76939-46-3]
Catalog
SLK-S7857
Brand
Selleck
CAS
76939-46-3
DESCRIPTION [76939-46-3]
Overview
| MDL | MFCD00005844 |
|---|---|
| Molecular Weight | 430.08 |
| Molecular Formula | C10H10BrN5NaO6P |
| SMILES | NC1=C(N=C(Br)N2[C@@H]3O[C@@](COP(O4)([O-])=O)([H])[C@]4([H])[C@H]3O)C2=NC=N1.[Na+] |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3251 mL | 11.6257 mL | 23.2515 mL |
| 5 mM | 0.4650 mL | 2.3251 mL | 4.6503 mL |
| 10 mM | 0.2325 mL | 1.1626 mL | 2.3251 mL |
| 50 mM | 0.0465 mL | 0.2325 mL | 0.4650 mL |
Description
8-bromo-cAMP (8-Br-Camp) is a cell permeable analog of that activates cyclic-AMP-dependent protein kinase with a Ka value of 0.05 μM; and a activator.
Targets
| PKA [1] |
| 0.05 μM(Ka) |
In vitro
8-Bromo-cAMP improves the reprogramming efficiency of human neonatal foreskin fibroblast (HFF1) cells. In bronchial epithelial cells, 8-Bromo-cAMP decreases HDE-stimulated tumor necrosis factor (TNF)-α-converting enzyme (TACE; ADAM-17) activity and subsequent TNF-α release.
References
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