[CAS NO. 305834-79-1] SC79

Name: SC79
Brand: Arctom Scientific
SKU: SLK-S7863

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PRODUCTS SPECIFICATIONS [305834-79-1]

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Catalog

SLK-S7863

Brand

Selleck

CAS

305834-79-1

DESCRIPTION [305834-79-1]

Overview

MDL	MFCD02681303
Molecular Weight	364.78
Molecular Formula	C17H17ClN2O5
SMILES	O=C(OCC)C(C#N)C1C(C(OCC)=O)=C(N)OC2=CC=C(Cl)C=C12

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.7414 mL	13.7069 mL	27.4138 mL
5 mM	0.5483 mL	2.7414 mL	5.4828 mL
10 mM	0.2741 mL	1.3707 mL	2.7414 mL
50 mM	0.0548 mL	0.2741 mL	0.5483 mL

Description

SC79 is a brain-penetrable phosphorylation activator and an inhibitor of Akt-PH domain translocation.

Targets

Akt ^[1]

In vitro

SC79 suppresses PH-GFP plasma membrane translocation, and enhances phosphorylation of all three Akt isoforms in HEK293, HeLa, HL60, NB4, and HsSulton (B cells) cells. SC79 reduces neuronal excitotoxicity and prevents stroke-induced neuronal death. SC79 restores proliferation of BRAT1 knockdown cells, and reduces the production of superoxide in mitochondria of MitoSox positive cells.

In vivo

In the permanent focal cerebral ischemia mouse model, SC79 (0.04 mg/g, i.p.) enables the cytosolic activation of Akt, and recapitulates the primary cellular function of Akt signaling, resulting in augmented neuronal survival.

References

[1] Jo H, et al. Proc Natl Acad Sci U S A. 2012, 109(26), 10581-10586.
[2] So EY, et al. BMC Cancer. 2014, 14, 548.