[CAS NO. 32619-42-4] Oleuropein

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PRODUCTS SPECIFICATIONS [32619-42-4]

Catalog

SLK-S7867

Brand

Selleck

CAS

32619-42-4

DESCRIPTION [32619-42-4]

Overview

MDL	MFCD16879008
Molecular Weight	540.51
Molecular Formula	C25H32O13
SMILES	C(C(OCCC1=CC(O)=C(O)C=C1)=O)[C@H]2/C(=C\C)/[C@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)OC=C2C(OC)=O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.8501 mL	9.2505 mL	18.5010 mL
5 mM	0.3700 mL	1.8501 mL	3.7002 mL
10 mM	0.1850 mL	0.9251 mL	1.8501 mL
50 mM	0.0370 mL	0.1850 mL	0.3700 mL

Description

Oleuropein is an antioxidant polyphenol isolated from olive leaf. Oleuropein exerts antioxidant, anti-inflammatory and anti-atherogenic effects and suppresses the adipocyte differentiation in vitro. Oleuropein inhibits activity. Oleuropein exerts anti-adipogenic effect through direct inhibition of PPARγ transcriptional activity. Oleuropein also inhibits . Oleuropein induces . Phase 2.

In vitro

In both J774A.1 cells and primary mouse macrophages, Oleuropein increases LPS-induced NO production. Oleuropein prevents oxidative myocardial injury induced by ischemia and reperfusion. In TF-1a; 786-O, T-47D, RPMI-7951, LoVo, and NL-Fib cells, Oleuropein inhibits cell proliferation and migration.

In vivo

In swiss albino mice that spontaneously develop soft tissue sarcomas, Oleuropein (i.p. or p.o.) completely regresses tumors. In rats, Oleuropein (40 mg/kg, p.o.) protects from cardiac remodeling process after isoproterenol-induced myocardial infarction through inhibiting angiotensin-converting enzyme activity.

References

[1] Visioli F, et al. Life Sci. 1998,62(6), 541-546.
[2] Manna C, et al. J Nutr Biochem. 2004, 15(8), 461-466.
[3] Hamdi HK, et al. Biochem Biophys Res Commun. 2005, 334(3), 769-778.
[4] Mnafgui K, et al. Toxicol Mech Methods. 2015, 1-9.

Synonyms

2H-Pyran-4-acetic acid, 3-ethylidene-2-(β-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-, 2-(3,4-dihydroxyphenyl)ethyl ester, (2S,3E,4S)-

2H-Pyran-4-acetic acid, 3-ethylidene-2-(β-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-, 2-(3,4-dihydroxyphenyl)ethyl ester, [2S-(2α,3E,4β)]-

Oleuropein

2H-Pyran-4-acetic acid, 5-carboxy-3-ethylidene-2-(β-D-glucosyloxy)-3,4-dihydro-, 3,4-dihydroxyphenethyl 5-methyl ester

Oleoeuropeine

Oleuropeine

Oleoeuropein

Opiace