[CAS NO. 20324-87-2] AMI-1

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PRODUCTS SPECIFICATIONS [20324-87-2]

Catalog

SLK-S7884

Brand

Selleck

CAS

20324-87-2

DESCRIPTION [20324-87-2]

Overview

MDL	MFCD00068249
Molecular Weight	548.45
Molecular Formula	C21H14N2Na2O9S2
SMILES	OC=1C2=C(C=C(S(=O)(=O)O)C1)C=C(NC(NC3=CC4=C(C=C3)C(O)=CC(S(=O)(=O)O)=C4)=O)C=C2.[Na]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.8233 mL	9.1166 mL	18.2332 mL
5 mM	0.3647 mL	1.8233 mL	3.6466 mL
10 mM	0.1823 mL	0.9117 mL	1.8233 mL
50 mM	0.0365 mL	0.1823 mL	0.3647 mL

Description

AMI-1 is a potent and specific inhibitor with of 3.0 μM and 8.8 μM for yeast Hmt1p and human PRMT1, respectively.

Targets

yeast Hmt1p ^[1] (Cell-free assay)	human PRMT1 ^[1] (Cell-free assay)
3.0 μM	8.8 μM

In vitro

In HeLa cells, AMI-1 inhibits methylation levels of GFP-Npl3 fusion and endogenous PRMT1-like activity. AMI-1 also inhibits nuclear receptor-mediated transactivation of a luciferase reporter in MCF7 cells. In addition, AMI-1 inhibits HIV-1 RT polymerase activity with IC50 of 5 μM and inhibits DNA binding to HIV-1 RT with Kd of 2 μM. In INS-1 cells, AMI-1 improves INS-1 cell function and mediates translocations of FOXO1 and PDX-1 intracellularly by regulating FOXO1 phosphorylation and methylation.

In vivo

In chronic AIPI rats, AMI-1 (5 μg/rat) ameliorates COX2 expression and asthmatic indexes, and decreases the airway and alveoli lesions, mucus secretion, and collagen deposition in lungs.

References

[1] Cheng D, et al. J Biol Chem. 2004, 279(23), 23892-23899.
[2] Skillman AG, et al. Bioorg Chem. 2002, 30(6), 443-458.
[3] Sun Q, et al. J Immunol. 2015, 195(1), 298-306.
[4] Lv L, et al. Endocrine. 2015,49(3), 669-682.

Synonyms

2-Naphthalenesulfonic acid, 7,7′-(carbonyldiimino)bis[4-hydroxy-, sodium salt (1:2)

2-Naphthalenesulfonic acid, 7,7′-ureylenebis[4-hydroxy-, disodium salt

2-Naphthalenesulfonic acid, 7,7′-(carbonyldiimino)bis[4-hydroxy-, disodium salt

AMI 1