[CAS NO. 6754-58-1] Xanthohumol

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Catalog:	SLK-S7889
Brand:	Selleck
CAS:	6754-58-1

Overview

MDL	MFCD00210576
Molecular Weight	354.4
Molecular Formula	C21H22O5
SMILES	C(/C=C/C1=CC=C(O)C=C1)(=O)C2=C(OC)C=C(O)C(CC=C(C)C)=C2O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.8217 mL	14.1084 mL	28.2167 mL
5 mM	0.5643 mL	2.8217 mL	5.6433 mL
10 mM	0.2822 mL	1.4108 mL	2.8217 mL
50 mM	0.0564 mL	0.2822 mL	0.5643 mL

Description

Xanthohumol, a prenylated chalcone from hop, inhibits and COX-2 activity and shows chemopreventive effects. Xanthohumol inhibits and with both IC50 of 40 μM. Xanthohumol is also a potent antiviral agent against a series of DNA and RNA viruses. Xanthohumol induces growth inhibition and in cancer cells. Phase 1.

Targets

COX-1 ^[1]	COX-2 ^[1]	DGAT1 ^[5] (Cell-free assay)	DGAT2 ^[5] (Cell-free assay)
		40 μM	40 μM

In vitro

Xanthohumol inhibits Cyp1A activity and induces QR activity in mouse hepatoma cell culture. Xanthohumol scavenges reactive oxygen species and inhibits superoxide anion radical and nitric oxide production. In addition, Xanthohumol prevents carcinogenesis via inhibition of DNA synthesis and induction of cell cycle arrest in S phase, apoptosis, and cell differentiation. Xanthohumol shows potent anti-HIV-1 activity.

References

[1] Gerhauser C, et al. Mol Cancer Ther. 2002, 1(11), 959-969.
[2] Wang Q, et al. Antiviral Res. 2004, 64(3), 189-194.
[3] Hirata H, et al. PLoS One. 2012, 7(11), e49415.
[4] Venè R, et al. Mol Med. 2012, 18, 1292-1302
[5] Junji Inokoshi, et al. J Antibiot (Tokyo) . 2009 Jan;62(1):51-4.

Synonyms

2-Propen-1-one, 1-[2,4-dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-, (2E)-

Xanthohumol

2-Propen-1-one, 1-[2,4-dihydroxy-6-methoxy-3-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-, (E)-

2-Propen-1-one, 1-[2,4-dihydroxy-6-methoxy-3-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-, (2E)-

(2E)-1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one

Xantho-Flav

Xantho Flav-Pure

Xanthopure

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