[CAS NO. 67526-95-8] Thapsigargin

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PRODUCTS SPECIFICATIONS [67526-95-8]

Catalog

SLK-S7895

Brand

Selleck

CAS

67526-95-8

DESCRIPTION [67526-95-8]

Overview

MDL	-
Molecular Weight	650.75
Molecular Formula	C34H50O12
SMILES	O(C(CCCCCCC)=O)[C@H]1[C@]2(C([C@]3([C@](O)([C@@H](OC(CCC)=O)C[C@@]2(OC(C)=O)C)[C@](C)(O)C(=O)O3)[H])=C(C)[C@@H]1OC(/C(=C\C)/C)=O)[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

Thapsigargin is a potent, non-competitive inhibitor of with IC50 of 0.353 nM or 0.448 nM for the carbachol-evoked [Ca2+]i-transients with or without a KCl-prestimulation. Thapsigargin induces cell . Thapsigargin is extracted from a plant, .

Targets

SERCA ^[1]

In vitro

In human SH-SY5Y neuroblastoma cells, two distinct intracellular Ca stores, a KCl-/caffeine-sensitive and a carbachol-/IP-sensitive store, are demonstrated previously. Thapsigargin (0.05 nM–20 μM) induces a [Ca]-transient. Thapsigargin inhibits the carbachol-evoked [Ca]-transients with (IC50 = 0.353 nM) or without (IC50 = 0.448 nM) a KCl-prestimulation. Thapsigargin is effective in inducing Endoplasmic Reticulum (ER) stress in hepatocytes.

References

[1] Zayra V Garavito-Aguilar, et al. Brain Res. 2004 Jun 18;1011(2):177-86.
[2] Hui Wang, et al. ScientificWorldJournal. 2014 Feb 9;2014:605416.
[3] Abdikarim Abdullahi, et al. Shock. 2017 Apr;47(4):506-513.

Synonyms

Octanoic acid, (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-buten-1-yl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl ester

Octanoic acid, 6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[(2-methyl-1-oxo-2-butenyl)oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl ester, [3S-[3α,3aβ,4α,6β,6aβ,7β,8α(Z),9bα]]-

Octanoic acid, (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl ester

Azuleno[4,5-b]furan, octanoic acid deriv.

Thapsigargin

(-)-Thapsigargin