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Catalog:
SLK-S7914
Brand:
Selleck
CAS:
832115-62-5
Overview
MDL
MFCD04133937
Molecular Weight
234.27
Molecular Formula
C11H10N2O2S
SMILES
O=C(C1=NOC(C2=CC=CS2)=C1)NC3CC3
For research use only.
Storage
3 years,-20°C,powder 1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
4.2686 mL
21.3429 mL
42.6858 mL
5 mM
0.8537 mL
4.2686 mL
8.5372 mL
10 mM
0.4269 mL
2.1343 mL
4.2686 mL
50 mM
0.0854 mL
0.4269 mL
0.8537 mL
Description
Isoxazole 9 (Isx-9) is a synthetic promotor of adult neurogenesis by triggering neuronal differentiation of adult neural stem/precursor cells (NSPCs). Isoxazole 9 (Isx-9) activates multiple pathways including induced epithelial–mesenchymal transition (EMT) signaling, canonical and non-canonical signaling at different stages of cardiac differentiation.
In vitro
In NSPCs, isoxazole 9 increases cell number, and promotes cell differentiation. In OPCs, isoxazole 9 induces cell damage. In outgrowth EPCs, isoxazole 9 decreases tube formation without effect on early EPCs.
In vivo
In mice, isoxazole 9 (20 mg/kg, i.p.) crosses the BBB and increases proliferation of neuroblasts and neurogenesis via Mef2-specific mechanisms in the hippocampal SGZ. Isoxazole 9 (20 mg/kg, i.p.) also increases differentiation and dendritic complexity of immature neurons and improves memory. In MWM, isoxazole 9 improves spatial memory.
