[CAS NO. 222638-67-7] BEC HCl

Name: BEC HCl
Brand: Arctom Scientific
SKU: SLK-S7929

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PRODUCTS SPECIFICATIONS [222638-67-7]

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Catalog

SLK-S7929

Brand

Selleck

CAS

222638-67-7

DESCRIPTION [222638-67-7]

Overview

MDL	MFCD03453539
Molecular Weight	229.49
Molecular Formula	C5H12BNO4S.HCl
SMILES	C(SCCB(O)O)[C@@H](C(O)=O)N.Cl

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

BEC HCl is a slow-binding, and competitive inhibitor with of 0.31 μM (pH7.5) and 0.4-0.6 μM for Arginase II and rat Arginase I, respectively.

Targets

Arginase II ^[1]	rat Arginase I ^[2]
0.31 μM(Ki)	<0.6 μM(Ki)

In vitro

BEC causes significant enhancement of NO-dependent smooth muscle relaxation. In myocytes, BEC augments Ca(2+)-dependent NOS activity and NO production, and increases basal contractility. BEC also inhibits the proliferation of human pulmonary artery smooth muscle cells by decreasing the expression levels of cyclin D1 and CDK4, increasing the expression of p27, and partly reducing the phosphorylation of Akt and ERK.

In vivo

In mice with allergic inflammation (OVA/OVA), BEC enhances peribronchiolar and perivascular inflammation, leads to enhanced NF-κB DNA binding and NF-κB-dependent inflammatory gene expression, and causes an increase in the content of NOx. In rats with pulmonary arterial hypertension, BEC reduces the right ventricle systolic pressure.

References

[1] Colleluori DM, et al. Biochemistry. 2001, 40(31), 9356-9362.
[2] Kim NN, et al. Biochemistry. 2001, 40(9), 2678-2688.
[3] Steppan J, et al. Proc Natl Acad Sci U S A. 2006, 103(12), 4759-4764.
[4] Ckless K, et al. J Immunol. 2008, 181(6), 4255-4264.
[5] Jiang W, et al. Mol Med Rep. 2015, 12(3), 4743-4749.

Synonyms

L-Cysteine, S-(2-boronoethyl)-, hydrochloride (1:1)

L-Cysteine, S-(2-boronoethyl)-, hydrochloride

BEC hydrochloride