[CAS NO. 724741-75-7] STF-31
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PRODUCTS SPECIFICATIONS [724741-75-7]
Catalog
SLK-S7931
Brand
Selleck
CAS
724741-75-7
DESCRIPTION [724741-75-7]
Overview
| MDL | MFCD04153828 |
|---|---|
| Molecular Weight | 423.53 |
| Molecular Formula | C23H25N3O3S |
| SMILES | O=C(NC1=CC=CN=C1)C2=CC=C(CNS(=O)(C3=CC=C(C(C)(C)C)C=C3)=O)C=C2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
STF-31 is a selective glucose transporter inhibitor.
Targets
| GLUT1 [1] |
In vitro
STF-31 selectively kills RCCs by specifically targeting glucose uptake through GLUT1. STF-31 significantly inhibits lactate production and extracellular acidification in VHL-deficient cells by about 60%, and decreases glycolysis by decreasing glucose transport. In NAPRT1-expressing cells, STF-31 shows cytotoxicity by inhibiting the enzymatic activity of NAMPT. STF-31 is toxic to hPSCs and efficient for selective elimination of hPSCs from mixed cultures.
In vivo
In mice with VHL-deficient RCC xenografts, a more soluble analog of STF-31 (11.6 mg/kg, i.p.) markedly delays tumor growth.
References
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