[CAS NO. 111540-00-2] Ochromycinone (STA-21)
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PRODUCTS SPECIFICATIONS [111540-00-2]
Store
Catalog
SLK-S7951
Brand
Selleck
CAS
111540-00-2
DESCRIPTION [111540-00-2]
Overview
| MDL | MFCD16883374 |
|---|---|
| Molecular Weight | 306.31 |
| Molecular Formula | C19H14O4 |
| SMILES | O=C1CC(C)CC2=CC=C3C(C(C4=CC=CC(O)=C4C3=O)=O)=C12 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.2647 mL | 16.3233 mL | 32.6467 mL |
| 5 mM | 0.6529 mL | 3.2647 mL | 6.5293 mL |
| 10 mM | 0.3265 mL | 1.6323 mL | 3.2647 mL |
| 50 mM | 0.0653 mL | 0.3265 mL | 0.6529 mL |
Description
Ochromycinone (STA-21) is a selective inhibitor.
Targets
| STAT3 [1] |
In vitro
In cells, STA-21 inhibits Stat3 DNA binding activity, Stat3 dimerization, and Stat3-dependent luciferase activity. STA-21 remarkably inhibits the growth and the survival of the breast carcinoma cells MDA-MB-231, MDA-MB-435s, and MDA-MB-468 that express persistently activated Stat3. In RH30 and RD2 cells, STA-21 also inhibits cell viability and growth and induced apoptosis through caspases 3, 8 and 9 pathways.
In vivo
In IL-1Ra–KO mice, STA-21 (0.5 mg/kg, i.p.) reduces the arthritis score and the incidence of arthritis by decreasing the proportion of Th17 cells and increasing the proportion of Treg cells expressing FoxP3.
References
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