[CAS NO. 14907-98-3] Brusatol

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [14907-98-3]

Catalog

SLK-S7956

Brand

Selleck

CAS

14907-98-3

DESCRIPTION [14907-98-3]

Overview

MDL	MFCD01746220
Molecular Weight	520.53
Molecular Formula	C26H32O11
SMILES	C(OC)(=O)[C@]12[C@]3([C@]4([C@@]([C@]5(C)[C@@](C[C@]4(OC(=O)[C@@H]3OC(C=C(C)C)=O)[H])(C(C)=C(O)C(=O)C5)[H])([C@@H](O)[C@@H]1O)[H])CO2)[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.9211 mL	9.6056 mL	19.2112 mL
5 mM	0.3842 mL	1.9211 mL	3.8422 mL
10 mM	0.1921 mL	0.9606 mL	1.9211 mL
50 mM	0.0384 mL	0.1921 mL	0.3842 mL

Description

Brusatol (NSC 172924), isolated from the fruit of , is a inhibitor.

Targets

Nrf2 ^[1]

In vitro

Brusatol provokes a rapid and transient depletion of Nrf2 protein, through a posttranscriptional mechanism, in mouse Hepa-1c1c7 hepatoma cells and freshly isolated primary human hepatocytes .

References

[1] Adedamola Olayanju, et al. Free Radic Biol Med. 2015, 78: 202-212.

Synonyms

Picras-3-en-21-oic acid, 13,20-epoxy-3,11,12-trihydroxy-15-[(3-methyl-1-oxo-2-buten-1-yl)oxy]-2,16-dioxo-, methyl ester, (11β,12α,15β)-

2H-3,11cβ-(Epoxymethano)phenanthro[10,1-bc]pyran-3α(3aβH)-carboxylic acid, 1,4,5,6aβ,7,7aα,10,11,11a,11bα-decahydro-1β,2α,4β,9-tetrahydroxy-8,11aβ-dimethyl-5,10-dioxo-, methyl ester, 4-(3-methylcrotonate)

Picras-3-en-21-oic acid, 13,20-epoxy-3,11,12-trihydroxy-15-[(3-methyl-1-oxo-2-butenyl)oxy]-2,16-dioxo-, methyl ester, (11β,12α,15β)-

Crotonic acid, 3-methyl-, 4-ester with methyl 1,4,5,6aβ,7,7aα,10,11,11a,11bα-decahydro-1β,2α,4β,9-tetrahydroxy-8,11aβ-dimethyl-5,10-dioxo-2H-3,11cβ-(epoxymethano)phenanthro[10,1-bc]pyran-3α(3aβH)-carboxylate

Brusatol

Yatansin

(+)-Brusatol

NSC 172924