Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
2.3701 mL
11.8506 mL
23.7012 mL
5 mM
0.4740 mL
2.3701 mL
4.7402 mL
10 mM
0.2370 mL
1.1851 mL
2.3701 mL
50 mM
0.0474 mL
0.2370 mL
0.4740 mL
Description
CCT251545 is a potent, orally bioavailable inhibitor of signaling with IC50 of 5 nM in 7dF3 cells. CCT251545 also act as a selective chemical probe for exploring the role of and in human disease.
The suppression of the WNT pathway activity by CCT251545 is not unique to a specific cell line, is independent of exogenous WNT pathway stimulation, does not result from destabilization of TCF1 or TCF4, and is not due to interference with the luciferase-based reporter readout. CCT251545 also demonstrates a lack of transporter-mediated efflux and a lack of activity across broad in vitro panels of enzyme, receptor, and ion channel targets.
