[CAS NO. 1108743-60-7] Entrectinib (RXDX-101)
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PRODUCTS SPECIFICATIONS [1108743-60-7]
Store
Catalog
SLK-S7998
Brand
Selleck
CAS
1108743-60-7
DESCRIPTION [1108743-60-7]
Overview
| MDL | MFCD28129099 |
|---|---|
| Molecular Weight | 560.64 |
| Molecular Formula | C31H34F2N6O2 |
| SMILES | N(C(=O)C1=C(NC2CCOCC2)C=C(C=C1)N3CCN(C)CC3)C=4C=5C(NN4)=CC=C(CC6=CC(F)=CC(F)=C6)C5 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.7837 mL | 8.9184 mL | 17.8368 mL |
| 5 mM | 0.3567 mL | 1.7837 mL | 3.5674 mL |
| 10 mM | 0.1784 mL | 0.8918 mL | 1.7837 mL |
| 50 mM | 0.0357 mL | 0.1784 mL | 0.3567 mL |
Description
Entrectinib (RXDX-101, NMS-E628) is an orally bioavailable pan-, and inhibitor with ranging between 0.1 and 1.7 nM. Entrectinib (RXDX-101) induces . Phase 2.
In vitro
Entrectinib selectively blocks proliferation of ALK-dependent cell lines and potently inhibits ALK‐dependent signaling. Entrectinib also highly inhibits cell growth of the NSCLC cell line NCI‐H2228 bearing the EML4-ALK rearrangement.
References
Synonyms
Benzamide, N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)amino]-
N-[5-[(3,5-Difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)amino]benzamide
Entrectinib
RXDX 101
NMS-E 628
Rozlytrek
NMS-E628
RXDX-101
RG 6268
RG6268
RG-6268
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