Overview MDL MFCD22378484 Molecular Weight 422.29 Molecular Formula C18H13Cl2N3O3S SMILES O=C(NC1=CC=C(S(=O)(NC2=CC=CC=C2Cl)=O)C(Cl)=C1)C3=NC=CC=C3
For research use only.
Storage 3 years,-20°C,powder
Shipping Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions Concentration Volume Mass 1 mg 5 mg 10 mg 1 mM 2.3680 mL 11.8402 mL 23.6804 mL 5 mM 0.4736 mL 2.3680 mL 4.7361 mL 10 mM 0.2368 mL 1.1840 mL 2.3680 mL 50 mM 0.0474 mL 0.2368 mL 0.4736 mL
Description VU 0364439 is a positive allosteric modulator (PAM), with of 19.8 nM.
Features The most potent mGlu4 PAM reported to date.
In vivo VU 0364439 possess less than ideal PK properties preventing their use as in vivo tools. It shows better stability in HLM (63% remaining) than RLM (2% remaining).
