[CAS NO. 1345675-02-6] ETP-46464
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PRODUCTS SPECIFICATIONS [1345675-02-6]
Store
Catalog
SLK-S8050
Brand
Selleck
CAS
1345675-02-6
DESCRIPTION [1345675-02-6]
Overview
| MDL | MFCD23160051 |
|---|---|
| Molecular Weight | 470.52 |
| Molecular Formula | C30H22N4O2 |
| SMILES | N#CC(C)(C)C1=CC=C(N(C2=C3C=NC4=CC=C(C5=CC6=CC=CC=C6N=C5)C=C24)C(OC3)=O)C=C1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1253 mL | 10.6265 mL | 21.2531 mL |
| 5 mM | 0.4251 mL | 2.1253 mL | 4.2506 mL |
| 10 mM | 0.2125 mL | 1.0627 mL | 2.1253 mL |
| 50 mM | - | - | - |
Description
ETP-46464 is a potent and selective inhibitor of with of 25 nM.
Features
Selective ATR inhibitor and particularly toxic to p53-deficient cancer cells. Often used as a pharmacologic probe due to its ideal pharmacological properties.
In vitro
ETP-46464 shows almost full activity against ATR at 100 nM. ETP-46464 inhibits the activity of PI3Kα, mTOR and DNA-PKcs with IC50s of 170, 0.6 and 36 nM. ETP-46464 is able to promote the breakage of stalled replication forks. Exposure to ETP-46464 leads the generation of substantial amounts of DNA damage in replicating cells. 1 μM ETP-46464 abrogates the ionizing radiation-induced G2/M checkpoint and leads to the presence of micronuclei or completely fragmented nuclei in cells. ETP-46464 is particularly toxic for p53-deficient cells, which is exacerbated by replicative stress-generating conditions such as the overexpression of cyclin E.
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