[CAS NO. 874902-19-9] LY-2183240
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PRODUCTS SPECIFICATIONS [874902-19-9]
Catalog
SLK-S8052
Brand
Selleck
CAS
874902-19-9
DESCRIPTION [874902-19-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 307.35 |
| Molecular Formula | C17H17N5O |
| SMILES | C(C=1N(C(N(C)C)=O)N=NN1)C2=CC=C(C=C2)C3=CC=CC=C3 |
For research use only.
Storage
2 years -80 in solvent
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.2536 mL | 16.2681 mL | 32.5362 mL |
| 5 mM | 0.6507 mL | 3.2536 mL | 6.5072 mL |
| 10 mM | 0.3254 mL | 1.6268 mL | 3.2536 mL |
| 50 mM | 0.0651 mL | 0.3254 mL | 0.6507 mL |
Description
LY-2183240 is a potent, covalent inhibitor of the EC-degrading enzyme . LY-2183240 disrupts the cellular uptake of the lipid endocannabinoid (EC) anandamide and promote analgesia in vivo. LY-2183240 is also an inhibitor of .
In vitro
LY2183240 inhibits anandamide uptake in live cell with IC50 of 0.27 nM. LY2183240 inactivates FAAH by carbamylation of the enzyme’s serine nucleophile. LY2183240 also inhibits KIAA1363, α/β-hydrolase 6 (Abh6) and monoacylglycerol lipase (MAG lipase) expressed in COS-7 cells with IC50 of 8.3, 0.09 and 5.3 nM, respectively.
References
Synonyms
1H-Tetrazole-1-carboxamide, 5-([1,1′-biphenyl]-4-ylmethyl)-N,N-dimethyl-
5-([1,1′-Biphenyl]-4-ylmethyl)-N,N-dimethyl-1H-tetrazole-1-carboxamide
LY 2183240
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