[CAS NO. 415713-60-9] RI-1

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PRODUCTS SPECIFICATIONS [415713-60-9]

Catalog

SLK-S8077

Brand

Selleck

CAS

415713-60-9

DESCRIPTION [415713-60-9]

Overview

MDL	MFCD00814248
Molecular Weight	361.61
Molecular Formula	C14H11Cl3N2O3
SMILES	O=C1N(C(=O)C(Cl)=C1N2CCOCC2)C3=CC(Cl)=C(Cl)C=C3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.7654 mL	13.8271 mL	27.6541 mL
5 mM	0.5531 mL	2.7654 mL	5.5308 mL
10 mM	0.2765 mL	1.3827 mL	2.7654 mL
50 mM	0.0553 mL	0.2765 mL	0.5531 mL

Description

RI-1 (RAD51 inhibitor 1) is a inhibitor with ranging from 5 to 30 μM.

Features

A selective recombinant RAD51 protein inhibitor discovered in 2012. Valuable tool for mechanistic studies of DNA repair and potential for use in many cancers.

Targets

RAD51 ^[1]

<30 μM

In vitro

RI-1 sensitizes cells to DNA damage by directly and specifically disrupting HsRAD51 and inhibiting the ability of RAD51 to form filaments on ssDNA. In addition, RI-1 alone generates single-agent toxicity in all three cancer cell lines (HeLa, MCF-7 and U2OS) with LD50 values in the 20–40 µM range. RI-1 decreases the rejoining of γ-H2AX foci in G2 phase cells and results in a higher level of unrepaired DSBs 6 hours after irradiation.

References

[1] Budke B, et al. Nucleic Acids Res. 2012, 40(15), 7347-7357.
[2] Bee L, et al. PLoS One. 2013, 8(7), e69061.

Synonyms

1H-Pyrrole-2,5-dione, 3-chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-

3-Chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione

RI 1

3-Chloro-1-(3,4-dichlorophenyl)-4-morpholin-4-ylpyrrole-2,5-dione

3-Chloro-1-(3,4-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione