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[CAS NO. 69-33-0] Tubercidin

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Catalog:	SLK-S8095
Brand:	Selleck
CAS:	69-33-0

Overview

MDL	MFCD00056012
Molecular Weight	266.25
Molecular Formula	C11H14N4O4
SMILES	O[C@H]1[C@](N2C=3C(C=C2)=C(N)N=CN3)(O[C@H](CO)[C@H]1O)[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

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Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.7559 mL	18.7793 mL	37.5587 mL
5 mM	0.7512 mL	3.7559 mL	7.5117 mL
10 mM	0.3756 mL	1.8779 mL	3.7559 mL
50 mM	0.0751 mL	0.3756 mL	0.7512 mL

Description

Tubercidin (7-deaza-adenosine), an adenosine analogue, is a . It is incorporated into DNA and inhibits polymerases, thereby inhibiting and . This agent also exhibits antifungal and antiviral activities.

In vitro

Continuous exposure for 14 days to tubercidin alone is highly toxic to both human CFU-GM and BFU-E. The IC50s of tubercidin are 3.4±1.7 and 3.7±0.2 nM for CFU-GM and BFU-E, respectively. Tubercidin also has a direct dose-dependent inhibitory effect on myeloid and erythroid human bone marrow progenitor cells in vitro.

In vivo

Tubercidin at the dose regimen (5 mg/kg everyday for 4 days) is lethal when used alone. Some of the studies show that the mortality from tubercidin is primarily due to hepatic and renal injuries and, to a lesser extent, damage to the pancreas. Coadministration of NBMPR-P at 25 mg/kg per day completely protects the mice (100% survival) from this lethal dose regimen of tubercidin.

References

[1] el Kouni MH, et al. Antimicrob Agents Chemother. 1989, 33(6):824-827.

Synonyms

7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-β-D-ribofuranosyl-

Tubercidin

7H-Pyrrolo[2,3-d]pyrimidine, 4-amino-7-β-D-ribofuranosyl-

7-β-D-Ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Adenosine, 7-deaza-

7-Deazaadenosine

Sparsomycin A

Tubercidine

U 10071

6-Amino-9-D-ribofuranosyl-7-desazapurine

NSC 56408

4-Amino-7-(β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine

Antibiotic XK 101-1

N⁷-Deazaadenosine

Sparsamycin A

NQZ-003

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