[CAS NO. 256376-24-6] BAY 41-2272

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [256376-24-6]

Catalog

SLK-S8128

Brand

Selleck

CAS

256376-24-6

DESCRIPTION [256376-24-6]

Overview

MDL	MFCD06411391
Molecular Weight	360.39
Molecular Formula	C20H17FN6
SMILES	C(N1N=C(C=2C1=NC=CC2)C=3N=C(N)C(=CN3)C4CC4)C5=C(F)C=CC=C5

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

BAY 41-2272 is a direct and NO-independent soluble (sGC) stimulator.

Targets

Guanylate cyclase ^[1]

In vitro

In vitro, BAY 41-2272 results in concentration dependent relaxation of human and rabbit cavernosum with EC50 of 489.1 nM and 406.3 nM, respectively.

In vivo

In female spontaneously hypertensive rats, BAY 41-2272 (10 mg/kg, p.o.) shows antiplatelet effect, strongly decreases blood pressure and increases survival. In C. albicans-infected mice, BAY 41-2272 (10 mg/kg, i.p.) markedly increases macrophage-dependent cell influx to the peritoneum in addition to macrophage functions, and reduces the death rate. In db/db-/- type II diabetic and obese mice, BAY 41-2272 improves impaired corpus cavernosum (CC) relaxation.

References

[1] Becker EM, et al. BMC Pharmacol. 2001, 1, 13.
[2] Stasch JP, et al. Nature. 2001, 410(6825), 212-215.
[3] Kalsi JS, et al. J Urol. 2003, 169(2), 761-766.
[4] Soeiro-Pereira PV, et al. Mem Inst Oswaldo Cruz. 2015, 110(1), 75-85.
[5] Nunes KP, et al. J Pharmacol Exp Ther. 2015, 353(2), 330-339.

Synonyms

4-Pyrimidinamine, 5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-

5-Cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-pyrimidinamine

BAY 41-2272