[CAS NO. 625115-55-1] Riociguat (BAY 63-2521)

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [625115-55-1]

Catalog

SLK-S8135

Brand

Selleck

CAS

625115-55-1

DESCRIPTION [625115-55-1]

Overview

MDL	MFCD19443708
Molecular Weight	422.42
Molecular Formula	C20H19FN8O2
SMILES	C(N1N=C(C=2C1=NC=CC2)C=3N=C(N)C(N(C(OC)=O)C)=C(N)N3)C4=C(F)C=CC=C4

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

Riociguat (BAY 63-2521) is an oral soluble stimulator, used in the treatment of ipulmonary hypertension.

Targets

guanylate cyclase ^[1]

In vitro

BAY 63-2521 stimulates the recombinant sGC concentration dependently from 0.1 to 100 μM with a two-fold to 73-fold effect by an NO-independent but haem-dependent mechanism. Riociguat inhibits platelet function in washed platelets but not in whole blood, and exerts no direct effects on contractility and relaxation of cardiac myocytes.

In vivo

In chronic treatment of hypoxic mice and MCT-injected rats, Riociguat (10 mg/kg/d, p.o.) partially reverses the pulmonary arterial hypertension, the right heart hypertrophy and the structural remodelling of the lung vasculature.

References

[1] Schermuly RT, et al. Eur Respir J. 2008, 32(4), 881-891.
[2] Reiss C, et al. Br J Pharmacol. 2015, 172(21), 5199-5210.
[3] Reinke Y, et al. Eur J Pharmacol. 2015, 767, 1-9.

Synonyms

Carbamic acid, N-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-methyl-, methyl ester

Carbamic acid, [4,6-diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]methyl-, methyl ester

Riociguat

BAY 632521

BAY 63-2521

Methyl [4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]methylcarbamate

Adempas

Methyl N-[4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-(methyl)carbamate