[CAS NO. 2095432-59-8] MS049

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PRODUCTS SPECIFICATIONS [2095432-59-8]

Catalog

SLK-S8147

Brand

Selleck

CAS

2095432-59-8

DESCRIPTION [2095432-59-8]

Overview

MDL	-
Molecular Weight	321.29
Molecular Formula	C15H26Cl2N2O
SMILES	O(CC1=CC=CC=C1)C2CCN(CCNC)CC2.Cl

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

MS049 is a potent and selective inhibitor of and with IC50s of 34 nM and 43 nM, respectively.

Targets

PRMT4 ^[1] (Cell-free assay)	PRMT6 ^[1] (Cell-free assay)
34 nM	43 nM

In vitro

MS049 does not inhibit any of the methyltransferases at 50 μM or demethylases at 10 μM and does not display appreciable binding to any of the methyllysine/methylarginine reader proteins using the DSF assay at 200 μM. MS049 demonstrated excellent selectivity over a broad range of epigenetic and nonepigenetic targets. In cellular assays, MS049 potently inhibits the methyltransferase activity of PRMT4 and PRMT6 and reduces levels of Med12me2a and H3R2me2a in HEK293 cells.

References

[1] Shen Y, et al. J Med Chem. 2016, 59(19):9124-9139.

Synonyms

1-Piperidineethanamine, N-methyl-4-(phenylmethoxy)-, hydrochloride (1:2)