[CAS NO. 1622849-58-4] GSK481
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PRODUCTS SPECIFICATIONS [1622849-58-4]
Catelog
SLK-S8169
Brand
Selleck
CAS
1622849-58-4
DESCRIPTION [1622849-58-4]
Overview
| MDL | MFCD30343843 |
|---|---|
| Molecular Weight | 377.39 |
| Molecular Formula | C21H19N3O4 |
| SMILES | O=C(C1=NOC(CC2=CC=CC=C2)=C1)N[C@H]3COC4=CC=CC=C4N(C)C3=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6498 mL | 13.2489 mL | 26.4978 mL |
| 5 mM | 0.5300 mL | 2.6498 mL | 5.2996 mL |
| 10 mM | 0.2650 mL | 1.3249 mL | 2.6498 mL |
| 50 mM | 0.0530 mL | 0.2650 mL | 0.5300 mL |
Description
GSK481 is a inhibitor. Inhibition of RIP1 has been shown to hinder cell necrotic death.
Targets
| RIP1 [1] |
In vitro
GSK481 can inhibit RIP1 WT S166 phosphorylation in human vs mouse plasmids overexpressed in HEK293T cells. GSK481 has approximately equivalent RIP1 FP potencies against human and cynomolgus monkey RIP1 but was >100-fold less potent against nonprimate RIP.
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