Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
2.5982 mL
12.9911 mL
25.9821 mL
5 mM
0.5196 mL
2.5982 mL
5.1964 mL
10 mM
0.2598 mL
1.2991 mL
2.5982 mL
50 mM
0.0520 mL
0.2598 mL
0.5196 mL
Description
ML264 (CID-51003603), a selectively inhibitor of ,potently Inhibits Growth of Colorectal Cancer.
Targets
KLF5 [1] (Cell-based assay for proliferation of DLD-1 cells)
29 nM
In vitro
ML264 potently halts DLD-1 viability (IC50 = 29 nM) with high maximal effect (>90%). DLD-1 cells are human colorectal adenocarcinoma cells. ML264 has significant effects at submicromolar doses on other cell types as well, including HCT116 (human colorectal carcinoma), HT29 (human colorectal adenocarcinoma), and SW620 (human colorectal adenocarcinoma). The IEC-6 anti-target (a nontransformed rat intestinal epithelial cell line) is largely unaffected, with inhibition below 50% at the highest dose.This compound potently inhibits proliferation of CRC cells in vitro through modifications of the cell cycle profile.
In vivo
In an established xenograft mouse model of colon cancer, ML264 efficiently inhibits growth of the tumor within five days of treatment. this effect is caused by a significant reduction in proliferation and that ML264 potently inhibits the expression of KLF5 and EGR1, a transcriptional activator of KLF5.
