[CAS NO. 1276121-88-0] PF-3644022
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PRODUCTS SPECIFICATIONS [1276121-88-0]
Catalog
SLK-S8224
Brand
Selleck
CAS
1276121-88-0
DESCRIPTION [1276121-88-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 374.46 |
| Molecular Formula | C21H18N4OS |
| SMILES | O=C1N[C@H](C)CNC2=C1SC3=CC=C4N=C(C5=CC=C(C)N=C5)C=CC4=C32 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6705 mL | 13.3526 mL | 26.7051 mL |
| 5 mM | 0.5341 mL | 2.6705 mL | 5.3410 mL |
| 10 mM | 0.2671 mL | 1.3353 mL | 2.6705 mL |
| 50 mM | 0.0534 mL | 0.2671 mL | 0.5341 mL |
In vitro
PF-3644022 is a potent freely reversible ATP-competitive compound that inhibits Mitogen-activated protein kinase-activated protein kinase 2(MK2) activity with good selectivity when profiled against 200 human kinases. In the human U937 monocytic cell line or peripheral blood mononuclear cells, PF-3644022 potently inhibits TNFα production with similar activity. PF-3644022 blocks TNFα and IL-6 production in LPS-stimulated human whole blood.[1]
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