[CAS NO. 312756-74-4] RS-1

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PRODUCTS SPECIFICATIONS [312756-74-4]

Catalog

SLK-S8234

Brand

Selleck

CAS

312756-74-4

DESCRIPTION [312756-74-4]

Overview

MDL	MFCD00348720
Molecular Weight	524.23
Molecular Formula	C20H16Br2N2O3S
SMILES	O=C(NC1=CC=C(Br)C=C1)C2=CC=C(Br)C(S(=O)(NCC3=CC=CC=C3)=O)=C2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.9076 mL	9.5378 mL	19.0756 mL
5 mM	0.3815 mL	1.9076 mL	3.8151 mL
10 mM	0.1908 mL	0.9538 mL	1.9076 mL
50 mM	0.0382 mL	0.1908 mL	0.3815 mL

Description

RS-1 is a RAD51-stimulatory compound, which increases the DNA binding activity of RAD51. It is an HDR(homology-directed repair) enhancer that enhances Cas9- and TALEN-mediated knock-in efficiency in rabbit embryos both in vitro and in vivo.

Targets

RAD51 ^[1]

In vitro

RS-1 stimulates the binding of hRAD51 to ssDNA. Low-micromolar concentrations of this small molecule enhance DNA binding and result in longer protein–DNA complex lengths. In addition, RS-1 stabilizes the active form of hRAD51 filaments and this is reflected in an enhanced strand assimilation activity. RS-1 enhances Cas9- and TALEN-mediated knock-in efficiency in rabbit embryos both in vitro and in vivo.

References

[1] Jayathilaka K, et al. Proc Natl Acad Sci U S A. 2008, 105(41):15848-53.
[2] Song J, et al. Nat Commun. 2016, 7:10548.