[CAS NO. 307538-42-7] SMER28

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PRODUCTS SPECIFICATIONS [307538-42-7]

Catalog

SLK-S8240

Brand

Selleck

CAS

307538-42-7

DESCRIPTION [307538-42-7]

Overview

MDL	MFCD02166825
Molecular Weight	264.12
Molecular Formula	C11H10BrN3
SMILES	N(CC=C)C=1C2=C(C=CC(Br)=C2)N=CN1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.7862 mL	18.9308 mL	37.8616 mL
5 mM	0.7572 mL	3.7862 mL	7.5723 mL
10 mM	0.3786 mL	1.8931 mL	3.7862 mL
50 mM	0.0757 mL	0.3786 mL	0.7572 mL

Description

SMER28 is a small-molecule enhancer (SMER) of autophagy, inducing independently of rapamycin in mammalian cells.

Targets

Autophagy ^[1]

In vitro

SMER28 is a positive regulator of autophagy in a mechanism independent from the mTOR pathway. It increases autophagosome synthesis and enhances the clearance of model autophagy substrates such as A53T a-synuclein and mutant huntingtin fragments. A marked decrease in Aβ/APP-CTF levels and enhancement for degradation of Aβ/APP-CTF via autophagy is also induced by SMER28. APP-CTF and LC3-II are cocompartmentalized on SMER28 treatment.

References

[1] Tian Y, et al. FASEB J. 2011, 25(6):1934-1942.

Synonyms

4-Quinazolinamine, 6-bromo-N-2-propen-1-yl-

4-Quinazolinamine, 6-bromo-N-2-propenyl-

6-Bromo-N-2-propen-1-yl-4-quinazolinamine

SMER 28