[CAS NO. 854107-55-4] Ponesimod

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [854107-55-4]

Catalog

SLK-S8241

Brand

Selleck

CAS

854107-55-4

DESCRIPTION [854107-55-4]

Overview

MDL	MFCD18207776
Molecular Weight	460.97
Molecular Formula	C23H25ClN2O4S
SMILES	O=C1N(C2=CC=CC=C2C)/C(S/C1=C\C3=CC=C(OC[C@H](O)CO)C(Cl)=C3)=N/CCC

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.1693 mL	10.8467 mL	21.6934 mL
5 mM	0.4339 mL	2.1693 mL	4.3387 mL
10 mM	0.2169 mL	1.0847 mL	2.1693 mL
50 mM	0.0434 mL	0.2169 mL	0.4339 mL

Description

Ponesimod (ACT-128800) is an orally active, selective immunomodulator with EC50 of 5.7 nM.

Targets

S1P1 receptor ^[1]
(In recombinant Chinese hamster ovary cells)

5.7 nM(EC50)

In vitro

Relative to the potency of S1P, the potency of ponesimod at human recombinant receptors was 4.4-fold higher for S1P1 and 150-fold lower for human S1P3. Therefore, ponesimod was ∼650-fold more selective for human S1P1 over S1P3 than the natural ligand.

References

[1] Piali L. et al. J Pharmacol Exp Ther. 2011, 337(2):547-556.
[2] D
[3] Piali L, et al. J Pharmacol Exp Ther. 2011 May;337(2):547-56.