Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
2.1693 mL
10.8467 mL
21.6934 mL
5 mM
0.4339 mL
2.1693 mL
4.3387 mL
10 mM
0.2169 mL
1.0847 mL
2.1693 mL
50 mM
0.0434 mL
0.2169 mL
0.4339 mL
Description
Ponesimod (ACT-128800) is an orally active, selective immunomodulator with EC50 of 5.7 nM.
Targets
S1P1 receptor [1] (In recombinant Chinese hamster ovary cells)
5.7 nM(EC50)
In vitro
Relative to the potency of S1P, the potency of ponesimod at human recombinant receptors was 4.4-fold higher for S1P1 and 150-fold lower for human S1P3. Therefore, ponesimod was ∼650-fold more selective for human S1P1 over S1P3 than the natural ligand.
