[CAS NO. 106566-58-9] Ossirene

Name: Ossirene
Brand: Arctom Scientific
SKU: SLK-S8301

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PRODUCTS SPECIFICATIONS [106566-58-9]

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Catalog

SLK-S8301

Brand

Selleck

CAS

106566-58-9

DESCRIPTION [106566-58-9]

Overview

MDL	MFCD01682758
Molecular Weight	312.05
Molecular Formula	C2H4Cl3O2Te.H4N
SMILES	[Cl-][Te+4]1([Cl-])([Cl-])[O-]CC[O-]1.[NH4+]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.2046 mL	16.0231 mL	32.0461 mL
5 mM	0.6409 mL	3.2046 mL	6.4092 mL
10 mM	0.3205 mL	1.6023 mL	3.2046 mL
50 mM	0.0641 mL	0.3205 mL	0.6409 mL

Description

AS101, a potent in vitro and in vivo immunomodulator, is a novel inhibitor of .

Targets

IL-1β converting enzyme ^[1]

In vitro

Treatment of caspase-1 (interleukin-1 [IL-1] converting enzyme [ICE]) with AS101 inhibits its enzymatic activity in a dose-dependent manner. Moreover, AS101 treatment causes a significant reduction in the active form of IL-18 and IL-1 in peripheral blood mononuclear cells (PBMC) and in human HaCat keratinocytes. The inhibitory effect of AS101 does not involve nitric oxide (NO) or interferon- (IFN- ), two possible regulators of IL-18 production, and does not occur at the mRNA level. It may exert effects through a posttranscriptional mechanism. AS101 induced SIRT1 expression in a dose dependent manner in three different cell lines, HEK293, HL-60 and Rin-5f. Incubation of HEK293 and HL-60 cell lines with AS101 (0.1-2.5μg/ml) resulted in a dose dependent reduction in PPARγ protein expression relative to the control cells, and the reduction of PPARγ expression is in parallel to increased SIRT1 expression.

In vivo

AS101 downregulates IL-18 and IL-1 serum levels in a mouse model of lipopolysaccharide (LPS)-induced sepsis, resulting in increased survival. It has also been shown to be protective against lethal and sublethal effects of irradiation and chemotherapy. In a model of cecal ligation and puncture (CLP)-induced sepsis in mice, AS101 also exerted beneficial effects. AS101 treated rats showed a large increase in SIRT1 protein levels in the liver and kidney extracts of rats treated with AS101. AS101 prevents development of insulin resistance in vivo. AS101 affects SIRT1 related metabolic pathways by changing the insulin levels. AS101 treatment prevents hyperglycemia associated with T2D(type 2 diabetes) and some of the symptoms of the disease in the HFD(high fat diet)+STZ(Streptozotocin) rat model.

References

[1] Brodsky M, et al. J Interferon Cytokine Res. 2007, 27(6):453-62.
[2] Halperin-Sheinfeld M, et al. Aging (Albany NY). 2012, 4(6):436-47.

Synonyms

Tellurate(1-), trichloro[1,2-ethanediolato(2-)-κO¹,κO²]-, ammonium (1:1), (SP-5-22)-

Tellurate(1-), trichloro[1,2-ethanediolato(2-)-O,O′]-, ammonium, (SP-5-22)-

1,2-Ethanediol, tellurium complex

AS 101 (pharmaceutical)

AS 101

Ossirene

Ammonium trichlorotellurate

Ammonium trichloro[1,2-ethanediolato-O,O′]-tellurate