TRC051384 is a compound that induces HSPA1A/B expression and subsequent Hsp70 production via heat shock factor-1 (HSF1) activation. TRC051384 increases HSP70B mRNA expression in both HeLa and primary mixed neuronal cells. Induction of HSP70 by TRC051384 involves HSF1 activation and results in elevated chaperone and anti-inflammatory activity.
In vivo
Treatment with TRC051384 significantly reduces stroke associated neuronal injury and disability in a rat model of transient ischemic stroke even when administered 8 hours post onset of ischemia. TRC051384 significantly reduces infarct size, brain edema and improves neurological deficit. TRC051384 delays thrombus formation in WT mice, the tail bleeding time still being unaltered.
