[CAS NO. 867164-40-7] TRC051384

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PRODUCTS SPECIFICATIONS [867164-40-7]

Catalog

SLK-S8305

Brand

Selleck

CAS

867164-40-7

DESCRIPTION [867164-40-7]

Overview

MDL	MFCD28133369
Molecular Weight	465.54
Molecular Formula	C25H31N5O4
SMILES	O=C(NC1=CC=C(C(/C=C/C2=NC(N3CCOCC3)=CC=C2)=O)C=C1)NCCN4CCOCC4

For research use only.

Storage

3 years -20°C(in the dark) powder
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

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Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.1480 mL	10.7402 mL	21.4804 mL
5 mM	0.4296 mL	2.1480 mL	4.2961 mL
10 mM	0.2148 mL	1.0740 mL	2.1480 mL
50 mM	0.0430 mL	0.2148 mL	0.4296 mL

Description

TRC051384 is an inducer of and potent anti-inflammatory agent.

Targets

HSP70 ^[1]

In vitro

TRC051384 is a compound that induces HSPA1A/B expression and subsequent Hsp70 production via heat shock factor-1 (HSF1) activation. TRC051384 increases HSP70B mRNA expression in both HeLa and primary mixed neuronal cells. Induction of HSP70 by TRC051384 involves HSF1 activation and results in elevated chaperone and anti-inflammatory activity.

In vivo

Treatment with TRC051384 significantly reduces stroke associated neuronal injury and disability in a rat model of transient ischemic stroke even when administered 8 hours post onset of ischemia. TRC051384 significantly reduces infarct size, brain edema and improves neurological deficit. TRC051384 delays thrombus formation in WT mice, the tail bleeding time still being unaltered.

References

[1] Mohanan A, et al. Neuropharmacology. 2011, 60(6):991-9.
[2] Allende M, et al. Cardiovasc Res. 2016, 110(3):309-18.