[CAS NO. 874911-96-3] ZK756326 2HCl
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PRODUCTS SPECIFICATIONS [874911-96-3]
Catalog
SLK-S8324
Brand
Selleck
CAS
874911-96-3
DESCRIPTION [874911-96-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 429.38 |
| Molecular Formula | C21H28N2O3.2HCl |
| SMILES | OCCOCCN1CCN(CC2=CC=CC(OC3=CC=CC=C3)=C2)CC1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3289 mL | 11.6447 mL | 23.2894 mL |
| 5 mM | 0.4658 mL | 2.3289 mL | 4.6579 mL |
| 10 mM | 0.2329 mL | 1.1645 mL | 2.3289 mL |
| 50 mM | 0.0466 mL | 0.2329 mL | 0.4658 mL |
Description
ZK756326 is a full agonist of with an IC50 of 1.8 μM, dose-responsively eliciting an increase in intracellular calcium and cross-desensitizing the response of the receptor to CCL1.
Targets
| CCR8 [1] (in U87 cell line) |
| 1.8 μM |
In vitro
ZK 756326 stimulated extracellular acidification in cells expressing human CCR8. The ability of ZK 756326 to induce a response was receptor-specific and mediated through Gαi, because it could be blocked by treatment with pertussis toxin. Like CCL1, ZK 756326 inhibited human immunodeficiency virus (HIV) fusion of cells expressing CD4 and CCR8. But unlike mCCL1, ZK 756326 bound to and activated a form of mCCR8 that was mutated to eliminate O-linked sulfation at tyrosines 14 and 15. Therefore, ZK 756326 is most probably not binding in the same manner as CCL1 but can activate the switch mechanism involved in transducing signaling events.
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