[CAS NO. 1821908-48-8] SGC2085

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PRODUCTS SPECIFICATIONS [1821908-48-8]

Catalog

SLK-S8340

Brand

Selleck

CAS

1821908-48-8

DESCRIPTION [1821908-48-8]

Overview

MDL	MFCD30537226
Molecular Weight	312.41
Molecular Formula	C19H24N2O2
SMILES	C[C@H](N)C(NCC1=CC=C(OC2=CC(C)=CC(C)=C2)C(C)=C1)=O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.2009 mL	16.0046 mL	32.0092 mL
5 mM	0.6402 mL	3.2009 mL	6.4018 mL
10 mM	0.3201 mL	1.6005 mL	3.2009 mL
50 mM	0.0640 mL	0.3201 mL	0.6402 mL

Description

SGC2085 is a potent and selective inhibitor with an IC50 value of 50 nM and >100-fold selective over other PRMTs.

Targets

CARM1 ^[1]
(Cell-free assay)

50 nM

In vitro

With the exception of PRMT6 (IC50 = 5.2 μM), SGC2085 does not inhibit other PRMTs. Although CARM1(PRMT4) is previously shown to asymmetrically dimethylate BAF155 at R1064, no cellular activity is observed for SGC2085 when tested up to 10 μM. The absence of cellular activity for SGC2085 may due to poor permeability.

References

[1] Ferreira de Freitas R, et al. J Med Chem. 2016, 59(14):6838-47.