[CAS NO. 1391426-24-6] Lys05

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PRODUCTS SPECIFICATIONS [1391426-24-6]

Catalog

SLK-S8369

Brand

Selleck

CAS

1391426-24-6

DESCRIPTION [1391426-24-6]

Overview

MDL	MFCD28963913
Molecular Weight	549.75
Molecular Formula	C23H23Cl2N5.3HCl
SMILES	N(CCN(CCNC=1C2=C(C=C(Cl)C=C2)N=CC1)C)C=3C4=C(C=C(Cl)C=C4)N=CC3.Cl

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

Lys05 is a new lysosomal inhibitor which potently accumulates within and deacidifies the lysosome of both cells and tumors, resulting in sustained inhibition of autophagy and tumor growth.

Targets

Autophagy ^[1]

In vitro

Lys05 is water soluble salt of Lys01. Lys05 shows potent antitumor activity as a single agent both in vitro and in vivo in multiple human cancer cell lines and xenograft models.Lys01 and Lys05 produce equivalent dose-dependent increases in the LC3II/LC3I ratio, accumulation of the autophagy cargo protein p62, and identical IC50 values in the MTT assay.

References

[1] Amaravadi RK, et al. Autophagy. 2012, 8(9):1383-4.
[2] McAfee Q, et al. Proc Natl Acad Sci U S A. 2012, 109(21):8253-8.
[3] Qiao X, et al. Blood Cancer J. 2021 Jun 7;11(6):111.

Synonyms

1,2-Ethanediamine, N²-(7-chloro-4-quinolinyl)-N¹-[2-[(7-chloro-4-quinolinyl)amino]ethyl]-N¹-methyl-, hydrochloride (1:3)

N-(7-Chloroquinolin-4-yl)-N′-[2-[(7-chloroquinolin-4-yl)amino]ethyl]-N′-methylethane-1,2-diamine trihydrochloride

Lys 05

N1-(7-Chloroquinolin-4-yl)-N2-[2-[(7-chloroquinolin-4-yl)amino]ethyl]-N2-methylethane-1,2-diamine trihydrochloride