[CAS NO. 97322-87-7] Troglitazone (CS-045)

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Catalog:	SLK-S8432
Brand:	Selleck
CAS:	97322-87-7

Overview

MDL	MFCD00878416
Molecular Weight	441.54
Molecular Formula	C24H27NO5S
SMILES	CC1=C2C(CCC(COC3=CC=C(CC4C(=O)NC(=O)S4)C=C3)(C)O2)=C(C)C(O)=C1C

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

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Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.2648 mL	11.3240 mL	22.6480 mL
5 mM	0.4530 mL	2.2648 mL	4.5296 mL
10 mM	0.2265 mL	1.1324 mL	2.2648 mL
50 mM	0.0453 mL	0.2265 mL	0.4530 mL

Description

Troglitazone (Rezulin, Romglizone, Prelay, CS045, Romozin) is a potent agonist for the that is a ligand activated transcription factor regulating cell differentiation and growth. Troglitazone induces , and necroptosis in bladder cancer cells. Troglitazone prevents RSL3-induced and lipid peroxidation in Pfa1 cells.

Targets

Ferroptosis ^[6]

PPAR ^[1]

In vitro

Troglitazone significantly inhibits cell growth by cell cycle arrest and apoptotic cell death. Troglitazone also downregulates surface expression of CD97, a novel dedifferentiation marker, in FTC-133 cells and upregulated sodium iodide symporter (NIS) mRNA in TPC-1 and FTC-133 cells. Troglitazone, a PPARγ agonist, induces antiproliferation and redifferentiation in thyroid cancer cell lines. Troglitazone induces Erk phosphorylation in human prostate cancer cells via a PPARγ-independent signaling pathway. TGZ(Troglitazone) up-regulates nitric oxide synthesis, induces the p53 pathway, inhibits cholesterol biosynthesis, induces p21 cyclin-dependent kinase inhibitor, has antioxidant function, and activates extracellular signal-regulated protein kinase (ERK) in a PPARγ-independent manner. TGZ induces Egr-1 expression by transcriptional and post-transcriptional regulation. Egr-1 induction by TGZ results in the increase of binding affinity and transactivation of the promoter containing Egr-1 consensus sequences, thereby possibly inducing other anti-tumorigenic proteins.

References

[1] Park JW, et al. Thyroid. 2005, 15(3):222-31.
[2] Bolden A, et al. PPAR Res. 2012, 2012:929052.
[3] Baek SJ, et al. J Biol Chem. 2003, 278(8):5845-53.
[4] van Westerloo DJ, et al. Am J Pathol. 2005, 166(3):721-8.
[5] Jaeschke H. Toxicol Sci. 2007, 97(1):1-3.
[6] Sebastian Doll, et al. Nat Chem Biol . 2017 Jan;13(1):91-98.

Synonyms

2,4-Thiazolidinedione, 5-[[4-[(3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-

5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione

CS 045

Troglitazone

Romglizone

GR 92132X

CI 991

Rezulin

Noscal

Depotox

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