[CAS NO. 1859141-26-6] ROC-325
Please click "REQUEST A QUOTE" button if you need other sizes or
custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis,
please:
PRODUCTS SPECIFICATIONS [1859141-26-6]
Catalog
SLK-S8527
Brand
Selleck
CAS
1859141-26-6
DESCRIPTION [1859141-26-6]
Overview
| MDL | MFCD31619252 |
|---|---|
| Molecular Weight | 503.06 |
| Molecular Formula | C28H27ClN4OS |
| SMILES | O=C1C2=C(SC3=C1C=CC=C3)C(C)=CC=C2NCCN(CCNC4=CC=NC5=CC(Cl)=CC=C45)C |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.9878 mL | 9.9392 mL | 19.8783 mL |
| 5 mM | 0.3976 mL | 1.9878 mL | 3.9757 mL |
| 10 mM | - | - | - |
| 50 mM | - | - | - |
Description
ROC-325 is an orally available novel inhibitor of lysosomal-mediated which diminishes AML cell viability with the IC50 range of 0.7-2.2 μM.
Targets
| Autophagy [1] |
In vitro
Treatment with ROC-325 triggers all of the hallmark features of autophagy inhibition including the accumulation of autophagosomes with undegraded cargo, an increase in lysosomal membrane permeability, deacidification of lysosomes, and elevated LC3B, p62, and cathepsin D expression. In vitro treatment of a panel of human AML cell lines and normal human bone marrow progenitors demonstrate that ROC-325 diminishes AML cell viability (IC50 range 0.7-2.2 µM), antagonizes clonogenic survival, and induces apoptosis in a manner that is therapeutically selective.
In vivo
ROC-325 is well tolerated and no notable toxicities are observed other than a modest, non-significant reversible reduction in mean body weight. Oral administration of ROC-325 to mice bearing RCC xenografts is well tolerated and yields dose-dependent inhibition of tumor growth that is significantly more efficacious than a higher dose of HCQ.
References
Powered by Arctom Copyright © 2025 Arctom.
All rights reserved.