[CAS NO. 1951483-29-6] Temuterkib (LY3214996)
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PRODUCTS SPECIFICATIONS [1951483-29-6]
Catalog
SLK-S8534
Brand
Selleck
CAS
1951483-29-6
DESCRIPTION [1951483-29-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 453.56 |
| Molecular Formula | C22H27N7O2S |
| SMILES | O=C1C(C=C(C2=NC(NC3=CC=NN3C)=NC=C2)S4)=C4C(C)(C)N1CCN5CCOCC5 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2048 mL | 11.0239 mL | 22.0478 mL |
| 5 mM | 0.4410 mL | 2.2048 mL | 4.4096 mL |
| 10 mM | 0.2205 mL | 1.1024 mL | 2.2048 mL |
| 50 mM | 0.0441 mL | 0.2205 mL | 0.4410 mL |
Description
Temuterkib (LY3214996) is a selective and novel inhibitor with IC50 of 5 nM for both enzymes in biochemical assays. It potently inhibits cellular phospho-RSK1 in BRAF and RAS mutant cancer cell lines.
In vitro
In an unbiased tumor cell panel sensitivity profiling for inhibition of cell proliferation, tumor cells with MAPK pathway alterations including BRAF, NRAS or KRAS mutation are generally sensitivity to LY3214996.LY3214996 possesses an optimal balance of potency (hERK1 IC50 5 nM, hERK2 IC50 5nM, pRSK IC50 0.43 µM) and solubility.
References
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