[CAS NO. 733030-01-8] TAS-102

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PRODUCTS SPECIFICATIONS [733030-01-8]

Catalog

SLK-S8539

Brand

Selleck

CAS

733030-01-8

DESCRIPTION [733030-01-8]

Overview

MDL	MFCD30481309
Molecular Weight	435.76
Molecular Formula	C10H11F3N2O5.0.5C9H11ClN4O2.0.5HCl
SMILES	O=C1N([C@@]2(O[C@H](CO)[C@@H](O)C2)[H])C=C(C(F)(F)F)C(=O)N1.C(C1=C(Cl)C(=O)NC(=O)N1)N2C(=N)CCC2.Cl

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.2948 mL	11.4742 mL	22.9484 mL
5 mM	0.4590 mL	2.2948 mL	4.5897 mL
10 mM	0.2295 mL	1.1474 mL	2.2948 mL
50 mM	0.0459 mL	0.2295 mL	0.4590 mL

Description

TAS-102 (Trifluridine-Tipiracil Hydrochloride Mixture) is an orally administered combination of a thymidine-based nucleic acid analogue, , and a thymidine phosphorylase inhibitor, .

In vitro

TAS-102 is an oral combination drug consisting of trifluridine (FTD), which is a thymidine-based nucleoside analog, and tipiracil hydrochloride (TPI), which improves the bioavailability of FTD by inhibiting its catabolism by thymidine phosphorylase (TP).Phosphorylated form of trifluridine is incorporated into DNA resulting in DNA dysfunction and cell cycle arrest. Thymidine phosphorylase inhibitor inhibits degradation of FTD and inhibits angiogenesis. Thus, TAS-102 treatment results in massive trifluridine incorporation into DNA and in activation of similar DNA damage response pathways, which involve phosphorylation of Chk1 and cycle arrest during the G2/M-phase.

References

[1] Lenz HJ, et al. Cancer Treat Rev. 2015, 41(9):777-83.
[2] Nukatsuka M, et al. Anticancer Res. 2015, 35(9):4605-15.
[3] Orlandi P, et al. Invest New Drugs. 2020 Feb;38(1):92-98.

Synonyms

Thymidine, α,α,α-trifluoro-, mixt. with 5-chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione hydrochloride (1:1)

Thymidine, α,α,α-trifluoro-, mixt. with 5-chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione monohydrochloride

TAS 102

Lonsurf

Trifluridine-tipiracil hydrochloride mixt.

Tipiracil hydrochloride-trifluridine mixt.

Trifluridine-tipiracil hydrochloride mixture

Trifluridine-tipiracil mixture

Tipiracil-trifluridine

Tipiracil-trifluridine mixture