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Catalog:
SLK-S8595
Brand:
Selleck
CAS:
1423821-88-8
Overview
MDL
-
Molecular Weight
3741.1
Molecular Formula
C164H251N57O45
SMILES
-
For research use only.
Storage
3 years,-20°C,powder 1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
0.2673 mL
1.3365 mL
2.6730 mL
5 mM
0.0535 mL
0.2673 mL
0.5346 mL
10 mM
0.0267 mL
0.1337 mL
0.2673 mL
50 mM
-
-
-
Description
Tat-beclin 1 (Tat-BECN1), a peptide known to stimulate through mobilization of endogenous , induces autophagy in vitro and in vivo and improves clinical outcomes.
Tat-beclin 1 is a cell-permeable peptide that induces autophagy. Treatment with Tat-beclin 1, but not Tat-scrambled, results in a dose-dependent decrease in amounts of p62, a selective autophagy substrate, and a dose-dependent conversion of the non-lipidated form of LC3, LC3-I, to the lipidated, autophagosome-associated form of LC3, LC3-II, in multiple cell lines and primary murine embryonic fibroblasts (MEFs). Tat-beclin 1 markedly inhibits HIV-1 replication in primary human monocyte-derived macrophages.
In vivo
Tat-beclin 1 can induce autophagy in peripheral tissues in adult mice as well as in the central nervous system of neonatal mice. Daily Tat-beclin 1 peptide treatment is well-tolerated in both neonatal and adult mice. Tat-beclin 1 peptide improves the clinical outcome of mice with CNS WNV(West Nile virus) infection.
