Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
1 mg
5 mg
10 mg
1 mM
2.0689 mL
10.3443 mL
20.6885 mL
5 mM
0.4138 mL
2.0689 mL
4.1377 mL
10 mM
0.2069 mL
1.0344 mL
2.0689 mL
50 mM
0.0414 mL
0.2069 mL
0.4138 mL
Description
Onametostat (JNJ-64619178) is a inhibitor with high selectivity and potency (subnanomolar range, PRMT5-MEP-50 IC50=0.14 nM) under different in vitro and cellular conditions, paired with favorable pharmacokinetics and safety properties.
JNJ-64619178 binds into the SAM binding pocket and reaches the substrate binding pocket to inhibit PRMT5/MEP50 function in a time-dependent manner. Broad cell line panel profiling of JNJ-64619178 reveals a wide range of sensitivity, which is indicative of a genomic dependency instead of a general cytotoxic on-target consequence of PRMT5 inhibition.
