[CAS NO. 2086772-26-9] Onametostat (JNJ-64619178)
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PRODUCTS SPECIFICATIONS [2086772-26-9]
Catalog
SLK-S8624
Brand
Selleck
CAS
2086772-26-9
DESCRIPTION [2086772-26-9]
Overview
| MDL | MFCD31813596 |
|---|---|
| Molecular Weight | 483.36 |
| Molecular Formula | C22H23BrN6O2 |
| SMILES | O[C@@H]1[C@H](O)[C@@H](CCC2=CC3=C(C=C(Br)C(N)=N3)C=C2)C[C@]1(N4C=CC5=C(N)N=CN=C45)[H] |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.0689 mL | 10.3443 mL | 20.6885 mL |
| 5 mM | 0.4138 mL | 2.0689 mL | 4.1377 mL |
| 10 mM | 0.2069 mL | 1.0344 mL | 2.0689 mL |
| 50 mM | 0.0414 mL | 0.2069 mL | 0.4138 mL |
Description
Onametostat (JNJ-64619178) is a inhibitor with high selectivity and potency (subnanomolar range, PRMT5-MEP-50 IC50=0.14 nM) under different in vitro and cellular conditions, paired with favorable pharmacokinetics and safety properties.
Targets
| PRMT5 [1] |
| 0.14 nM |
In vitro
JNJ-64619178 binds into the SAM binding pocket and reaches the substrate binding pocket to inhibit PRMT5/MEP50 function in a time-dependent manner. Broad cell line panel profiling of JNJ-64619178 reveals a wide range of sensitivity, which is indicative of a genomic dependency instead of a general cytotoxic on-target consequence of PRMT5 inhibition.
References
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