[CAS NO. 2049868-46-2] GSK'963
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PRODUCTS SPECIFICATIONS [2049868-46-2]
Catalog
SLK-S8642
Brand
Selleck
CAS
2049868-46-2
DESCRIPTION [2049868-46-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 230.31 |
| Molecular Formula | C14H18N2O |
| SMILES | CC(C)(C)C(N1N=CC[C@H]1C2=CC=CC=C2)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.3420 mL | 21.7099 mL | 43.4197 mL |
| 5 mM | 0.8684 mL | 4.3420 mL | 8.6839 mL |
| 10 mM | 0.4342 mL | 2.1710 mL | 4.3420 mL |
| 50 mM | 0.0868 mL | 0.4342 mL | 0.8684 mL |
Description
GSK'963 is a chiral small-molecule inhibitor of with an IC50 of 29 nM in FP binding assays. It is >10 000-fold selective for RIP1 over 339 other kinases.
Targets
| RIP1 kinase [1] (Cell-free assay) |
| 29 nM |
In vitro
GSK'963 inhibits RIP1-dependent cell death with an IC50 of between 1 and 4 nM in human and murine cells.
In vivo
GSK'963 is a potent inhibitor of a TNF+zVAD-mediated lethal shock. At 2 mg/kg, GSK'963 would maintain blood concentrations above the concentration required for 90% inhibition of RIP1 activity for an extended period of time compared with Nec-1.
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