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[CAS NO. 432001-69-9]
Skp2 inhibitor C1 (SKPin C1)
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PRODUCTS SPECIFICATIONS [432001-69-9]
Catalog
SLK-S8652
Brand
Selleck
CAS
432001-69-9
DESCRIPTION [432001-69-9]
Overview
MDL
-
Molecular Weight
465.34
Molecular Formula
C18H13BrN2O4S2
SMILES
O=C(O)COC1=CC=C(Br)C=C1/C=C(SC(N2CC3=CC=CN=C3)=S)/C2=O
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
Skp2 inhibitor C1 (SKPin C1) is a specific and selective small-molecule inhibitor of by reducing p27 binding through key compound-receptor contacts.
Targets
p27 degradation
[1]
In vitro
Skp2 inhibitor C1 treatment of MCF-7 breast cancer cells lines does not increase, but rather decrease the percentage of cells in G1 while increasing the G2/M population.
References
[1] Lily Wu, et al. Chem Biol. 2012, 19(12): 1515–1524.